Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine
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N K Berdinskikh1, N A Ignatenko, S P Zaletok
1Department of Tumor Biochemistry, R.E. Kavetsky Institute for Oncological Problems, Academy of Sciences, Ukrainian SSR, Kiev.
Abstract:
Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.