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Updated: Jun 18, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis
Konstantinos A Toulis1, Dimitrios G Goulis, Christos A Venetis
1Unit of Reproductive Endocrinology Unit for Human Reproduction, First Department of Obstetrics and Gynecology, Medical School, Papageorgiou General Hospital, Aristotle University, Ring Road, Nea Efkarpia, 56403 Thessaloniki, Greece. toulis@endo.gr
Objective:
To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF.
Design:
Meta-analysis of observational studies.
Patient(S):
Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis.
Main Outcome Measure:
Miscarriage risk ratio (RR).
Secondary Outcome Measures:
Clinical pregnancy rate and delivery rate.
Result(S):
Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42- 2.79, P<0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups.
Conclusion:
Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.
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