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Updated: Jun 18, 2026

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
C. Diff Quik Chek complete enzyme immunoassay provides a reliable first-line method for detection of Clostridium
Criziel D Quinn1, Susan E Sefers, Wisal Babiker
1Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Abstract:
We evaluated a single membrane device assay for simultaneously detecting both Clostridium difficile glutamate dehydrogenase (GDH) and toxin A/B antigens against a standard that combines two PCR assays and cytotoxigenic culture. Results showing dual GDH and toxin A/B antigen positives and negatives can be reported immediately as true positives and negatives, respectively. Specimens with discrepant results for GDH and toxins A/B, which comprised 13.2% of the specimens, need to be retested.
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