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Definitive radiation therapy for localized prostatic adenocarcinoma
G Arcangeli1, A Micheli, G Arcangeli
1Radiotherapy Service, G. Porfiri Oncology Center, S. Maria Goretti Hospital Latina, Italy.
Summary
External beam radiation therapy effectively controls localized prostate cancer, offering good survival rates and acceptable complication incidence. This treatment is a safe and efficacious option for managing pelvic prostate cancer.
Area of Science:
- Oncology
- Radiation Oncology
- Urologic Oncology
Background:
- Prostate cancer is a significant health concern, necessitating effective treatment strategies.
- External beam radiation therapy (EBRT) is a primary modality for localized prostate cancer.
Purpose of the Study:
- To evaluate the efficacy and safety of definitive external beam radiation therapy for localized prostate cancer.
- To assess long-term survival outcomes and complication rates associated with EBRT in prostate cancer patients.
Main Methods:
- Retrospective analysis of 199 patients with localized prostate cancer treated with EBRT between 1974 and 1987.
- Median follow-up of 60 months for surviving patients.
- Calculation of actuarial overall, disease-specific, and disease-free survival rates based on U.I.C.C. clinical stages.
Main Results:
- 5-year overall survival rates ranged from 76.1% (Stage T1-2) to 27.6% (Stage T4).
- Disease-specific survival rates at 5 years were 81.7% (T1-2), 72.5% (T3), and 36.2% (T4).
- Local failure occurred in 6.6% of patients with over 5 years of follow-up; serious complications were rare (1.3%).
Conclusions:
- External beam radiation therapy demonstrates efficacy in achieving locoregional control for prostate cancer.
- The treatment offers favorable long-term survival outcomes with an acceptable safety profile.
- EBRT is a safe and effective therapeutic option for managing localized prostate cancer.