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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Ischemic perinatal stroke secondary to chorioamnionitis: a histopathological case presentation
Christine C Dueck1, David Grynspan, David D Eisenstat
1Department of Pediatrics and Child Health, University of Manitoba, Health Sciences Centre, Manitoba, Canada.
Journal of Child Neurology
|December 4, 2009
Summary
Severe chorioamnionitis, a uterine infection, may cause ischemic perinatal stroke in newborns. Umbilical vein thrombosis linked to this infection might be a key mechanism.
Area of Science:
- Perinatal neurology
- Neonatal infections
- Obstetrics
Background:
- Ischemic perinatal stroke is a significant delivery complication.
- In utero infections are an underrecognized cause of perinatal stroke.
- Objective evidence linking uterine infection to ischemic stroke is limited.
Observation:
- A term neonate presented with seizures on day 3 of life.
- Investigations ruled out metabolic, infectious, and hypercoagulability causes.
- MRI revealed extensive acute infarction in the left middle cerebral artery territory.
Findings:
- Placental histopathology confirmed severe chorioamnionitis.
- Umbilical vein thrombosis was present.
- The neonate developed ischemic perinatal stroke.
Implications:
- Chorioamnionitis is a potential cause of ischemic perinatal stroke.
- Umbilical vein thrombosis and paradoxical embolization may be a mechanism.
- This association highlights the importance of managing maternal infections during pregnancy.
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