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Updated: Jun 18, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Ischemic perinatal stroke secondary to chorioamnionitis: a histopathological case presentation

Christine C Dueck1, David Grynspan, David D Eisenstat

  • 1Department of Pediatrics and Child Health, University of Manitoba, Health Sciences Centre, Manitoba, Canada.

Journal of Child Neurology
|December 4, 2009
PubMed

Ischemic perinatal stroke is a serious potential complication of delivery. In utero infection may be responsible for an underestimated proportion of perinatal stroke. Limited literature identifies objective evidence of ischemic perinatal stroke as a consequence of uterine infection. The authors report a neonate with ischemic stroke and documented findings of severe chorioamnionitis with umbilical vein thrombosis. A term neonate, after uneventful pregnancy and delivery, presented on the third day of life with seizures. Investigations for metabolic, electrolyte, infectious, and hypercoaguability derangements were normal. Extensive acute infarction in the left middle cerebral artery territory was diagnosed by magnetic resonance imaging (MRI). Placental histopathology confirmed the presence of chorioamnionitis. On follow-up assessments, mild residual neurologic deficits have persisted. Chorioamnionitis has been correlated with ischemic perinatal stroke. In addition to the recognized inflammatory cascade of in utero infection, umbilical vein thrombosis with subsequent ''paradoxical'' embolization may represent one mechanism responsible for this association.

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