Related Experiment Video
Updated: Jun 18, 2026
04:41
Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice
Published on: February 24, 2026
An engineered solution to the maladministration of spinal injections.
1Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT UK. r.j.lawton@leeds.ac.uk
Quality & Safety in Health Care
|December 4, 2009
Summary
Dedicated spinal equipment incompatible with Luer syringes can prevent misconnections during spinal injections. A modified non-Luer system showed improved clinician satisfaction and is progressing to clinical evaluation.
Area of Science:
- Medical device engineering
- Patient safety in healthcare
Background:
- The Department of Health (DH) is addressing spinal injection maladministration.
- Misconnection errors with standard Luer syringes pose a risk in spinal procedures.
Purpose of the Study:
- To implement an engineered solution to prevent spinal injection misconnections.
- To investigate dedicated spinal equipment incompatible with Luer devices.
Main Methods:
- Systematic approach to eradicate misconnection errors.
- Bench-testing of non-Luer connectors.
- Hazard analysis of spinal procedures.
- Usability evaluation of prototype devices.
Main Results:
- Two potential risks identified requiring management for implementation.
- One prototype design deemed inadequate due to a separable adapter.
- A modified second connection system showed improved clinician satisfaction.
Conclusions:
- The second, modified non-Luer connection system was selected for further evaluation.
- The chosen system is undergoing pre-implementation assessment.
- Clinical acceptability of the modified system is currently being evaluated.
More Related Videos
Related Concept Videos
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
01:29Drug Delivery: Parenteral Route
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...