Watchful waiting in the treatment of the small renal mass

K Clint Cary1, Chandru P Sundaram

  • 1Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.

Insights

Observation is a viable option for managing small renal masses, especially in elderly or surgically unfit patients. While percutaneous biopsy can detect malignancy, further research on natural history and metastatic potential is needed.

Area of Science:

  • Nephrology
  • Urology
  • Oncology

Background:

  • Small renal masses (SRMs) present a clinical challenge regarding optimal management.
  • Understanding the natural history and metastatic potential of SRMs is crucial for treatment decisions.

Purpose of the Study:

  • To evaluate the role and feasibility of observation for small renal masses.
  • To review the literature on the natural history, percutaneous biopsy, and surveillance of SRMs.

Main Methods:

  • A comprehensive literature search of MEDLINE was conducted.
  • Reviewed studies focused on the natural history, percutaneous biopsy, and surveillance of SRMs.

Main Results:

  • SRMs typically grow at 0.1–0.70 cm/yr, with unreliable clinical predictors of growth.
  • Metastatic disease develops in approximately 1% of SRMs under surveillance.
  • Percutaneous biopsy demonstrates 90%-98% sensitivity for malignancy, though false negatives can occur.

Conclusions:

  • Observation ('watchful waiting') is a suitable management strategy for SRMs in elderly or surgically unfit individuals.
  • Further research is required to fully elucidate the natural history and metastatic potential of SRMs.
  • Percutaneous needle biopsy is a valuable tool for detecting malignancy in selected SRM patients, with its role continuing to evolve.

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