Related Experiment Video
Updated: Jun 18, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Watchful waiting in the treatment of the small renal mass
K Clint Cary1, Chandru P Sundaram
1Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.
Abstract:
Objectives : To evaluate the role and feasibility of observation with regard to the small renal mass. Methods : We performed a literature search of MEDLINE, reviewing the world literature relevant to the natural history, role of percutaneous biopsy and surveillance of the small renal mass. Results : The average yearly growth rate of most small renal masses ranges from 0.1 to 0.70 cm/yr with obvious exceptions. Clinical predictors of growth such as radiographic size at presentation, age, gender and tumor characteristics are not reliable. Approximately 1% develops metastatic disease while under surveillance. Contemporary series of percutaneous biopsy of small renal masses report sensitivity for malignancy to be 90%-98%. However, false-negative results can occur. For the majority of patients, the gold standard remains surgical extirpation. Conclusions : Watchful waiting is an acceptable option for management of small renal masses in the surgically unfit and elderly population. More information regarding the natural history and metastatic potential of small renal masses is needed. Percutaneous needle biopsy can be successful in detecting malignancy in selected patients with small renal masses. The role of needle biopsy for the small renal mass continues to evolve.
Insights
Observation is a viable option for managing small renal masses, especially in elderly or surgically unfit patients. While percutaneous biopsy can detect malignancy, further research on natural history and metastatic potential is needed.
Area of Science:
- Nephrology
- Urology
- Oncology
Background:
- Small renal masses (SRMs) present a clinical challenge regarding optimal management.
- Understanding the natural history and metastatic potential of SRMs is crucial for treatment decisions.
Purpose of the Study:
- To evaluate the role and feasibility of observation for small renal masses.
- To review the literature on the natural history, percutaneous biopsy, and surveillance of SRMs.
Main Methods:
- A comprehensive literature search of MEDLINE was conducted.
- Reviewed studies focused on the natural history, percutaneous biopsy, and surveillance of SRMs.
Main Results:
- SRMs typically grow at 0.1–0.70 cm/yr, with unreliable clinical predictors of growth.
- Metastatic disease develops in approximately 1% of SRMs under surveillance.
- Percutaneous biopsy demonstrates 90%-98% sensitivity for malignancy, though false negatives can occur.
Conclusions:
- Observation ('watchful waiting') is a suitable management strategy for SRMs in elderly or surgically unfit individuals.
- Further research is required to fully elucidate the natural history and metastatic potential of SRMs.
- Percutaneous needle biopsy is a valuable tool for detecting malignancy in selected SRM patients, with its role continuing to evolve.
Related Concept Videos
Kidney Transplant III: Nursing Management
Kidney Transplant II: Surgical Procedure
Urinary Tract Calculi III: Medical Management
Nursing Assessment of the Genitourinary System II: Inspection and Palpation
Chronic Kidney Disease III: Interprofessional Care
Imaging Studies III: Computed Tomography

