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Related Experiment Videos

Histopathologic study of uveitis in cats: 139 cases (1978-1988).

R L Peiffer1, B P Wilcock

  • 1Department of Ophthalmology, School of Medicine, University of North Carolina, Chapel Hill 27599-7040.

Journal of the American Veterinary Medical Association
|January 11, 1991
PubMed
Summary

The most common cause of uveitis in cats is a lymphocytic-plasmacytic infiltrate, often without a specific identifiable cause. Other frequent causes include feline infectious peritonitis and FeLV-associated lymphosarcoma.

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Area of Science:

  • Veterinary Pathology
  • Ophthalmology
  • Feline Medicine

Background:

  • Uveitis is a common ocular condition in cats, presenting diagnostic challenges.
  • Understanding the histopathologic basis of feline uveitis is crucial for accurate diagnosis and treatment.
  • Previous studies have identified various causes, but a comprehensive histopathologic correlation is often lacking.

Purpose of the Study:

  • To compare histopathologic findings in feline globes with uveitis.
  • To correlate morphologic features with clinical and histopathologic diagnoses.
  • To identify the most common causes and patterns of uveitis in cats.

Main Methods:

  • Histopathologic examination of 158 feline globes from enucleation or necropsy.
  • Correlation of morphologic findings with clinical and/or histopathologic diagnoses.

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  • Classification of uveitis based on cellular infiltrate and etiology.

    • Main Results:

    • Lymphocytic-plasmacytic anterior uveal infiltrate was the most common finding (nongranulomatous anterior uveitis).
    • A specific cause was not identified for the majority of these lymphocytic-plasmacytic cases.
    • Other significant causes, in decreasing order of frequency, were feline infectious peritonitis, FeLV-associated lymphosarcoma, trauma, and lens-induced uveitis.

    Conclusions:

    • Nongranulomatous anterior uveitis with lymphocytic-plasmacytic infiltrate is the predominant histopathologic pattern in feline uveitis.
    • While common, the specific etiology for this pattern remains elusive in many cases.
    • Feline infectious peritonitis, FeLV-associated lymphosarcoma, trauma, and lens-induced uveitis are important identifiable causes of feline uveitis.