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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Updated: Jun 18, 2026

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
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Published on: November 18, 2019

Proteomic profiling in ovarian cancer.

Geoffrey Kim1, Lucas Minig, Elise C Kohn

  • 1Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20891, USA. kimgeof@mail.nih.gov

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|December 4, 2009
PubMed
Summary

Proteomic profiling shows promise for early ovarian cancer detection and personalized treatment. This approach aids in understanding tumor heterogeneity and guides targeted therapies for improved patient outcomes.

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Area of Science:

  • Oncology
  • Proteomics
  • Biomarker Discovery

Background:

  • Ovarian cancer is a leading cause of gynecologic cancer mortality.
  • Late-stage diagnosis limits curative treatment options.

Purpose of the Study:

  • To elucidate the role of proteomic profiling in ovarian cancer diagnosis and treatment.
  • To explore proteomic techniques for early detection and recurrence monitoring.

Main Methods:

  • Comprehensive literature review.
  • Analysis of ongoing clinical trials.
  • Review of institutional experience with proteomic profiling.

Main Results:

  • Proteomic techniques like mass spectrometry offer potential for early ovarian cancer detection.
  • Proteomic analysis reveals significant tumor heterogeneity.
  • Validated proteomic assays can refine tumor classification and guide personalized treatment.

Conclusions:

  • Proteomic profiling is crucial for developing multimodality screening programs.
  • Tailored treatment strategies based on individual tumor proteomic profiles can improve patient outcomes.
  • Proteomic profiling aids in assessing therapeutic efficacy and developing novel treatment combinations.