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Updated: Jun 18, 2026
09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
MicroRNAs as potential cancer therapeutics
P Trang1, J B Weidhaas, F J Slack
1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
Oncogene
|December 4, 2009
Summary
MicroRNAs (miRNAs) are crucial in cell functions and cancer development. This review explores their potential as biomarkers for cancer diagnosis, prognosis, and therapy.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) regulate fundamental cellular processes including apoptosis, differentiation, and development.
- Aberrant miRNA expression is frequently observed in human cancers.
- MiRNAs can function as either oncogenes or tumor suppressors in cancer progression.
Purpose of the Study:
- To review the role of microRNAs in human cancers.
- To explore the potential of miRNAs as biomarkers for cancer management.
- To discuss the application of miRNAs in cancer diagnosis, prognosis, and therapy.
Main Methods:
- Literature review of recent studies on microRNAs and cancer.
- Analysis of miRNA mis-expression patterns in various human malignancies.
- Evaluation of the diagnostic and prognostic value of miRNAs.
- Assessment of therapeutic strategies involving miRNAs.
Main Results:
- MiRNAs are significantly mis-expressed in diverse human cancers.
- These mis-expressed miRNAs can act as oncogenes or tumor suppressors.
- Evidence suggests miRNAs hold promise as sensitive and specific biomarkers.
- MiRNA-based therapies are emerging as a novel treatment modality.
Conclusions:
- MicroRNAs represent a significant area of research in oncology.
- Their dysregulation in cancer highlights their critical roles.
- MiRNAs offer substantial potential for improving cancer diagnosis, prognosis, and treatment strategies.
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