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Related Experiment Video

Updated: Jun 18, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Visual cortex plasticity evokes excitatory alterations in the hippocampus.

Marian Tsanov¹, Denise Manahan-Vaughan

¹Department of Experimental Neurophysiology, Medical Faculty, Ruhr University Bochum Bochum, Germany.

Frontiers in Integrative Neuroscience

|December 4, 2009

Summary

Novel visual information processing in the visual cortex (VC) enhances hippocampal theta rhythm, driving synaptic plasticity. This cortico-hippocampal dialogue is crucial for memory formation.

Keywords:

dentate gyrus in vivo oscillations visual cortex

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Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

Area of Science:

Neuroscience
Cognitive Neuroscience
Systems Neuroscience

Background:

Episodic memory integration in the hippocampus relies on theta rhythm oscillations and cortico-hippocampal interactions.
The visual cortex (VC) significantly influences hippocampal processing, potentially modulating its network oscillations and synaptic plasticity.

Purpose of the Study:

To investigate the correlation between visual cortex (VC) activity and hippocampal oscillatory and synaptic responsiveness.
To determine if VC plasticity influences hippocampal plasticity and memory consolidation.

Main Methods:

Recording field activity in the primary VC and hippocampus (dentate gyrus, DG) of freely behaving rats.
Using sensory or electrical stimulation in the VC and theta-burst stimulation in the dorsal lateral geniculate nucleus to mimic thalamocortical activity.
Analyzing spectral power of theta rhythm, high-frequency oscillations, and neuronal excitability, alongside cortico-hippocampal synchrony.

Main Results:

VC high-frequency oscillations correlate with increased hippocampal theta rhythm power, dependent on exploratory activity.
Stimulating thalamocortical pathways induces hippocampal theta increase and persistent DG potentiation, mirroring VC plasticity.
Enhanced VC and DG activity show negative synchronization of low-frequency oscillations, reduced during familiar environment exploration.

Conclusions:

Novel visual information drives hippocampal theta rhythm and plasticity through cortico-hippocampal interactions.
VC plasticity is tightly linked to DG neuronal excitability potentiation.
This cortico-hippocampal dialogue may serve as an endogenous trigger for long-term synaptic plasticity in the hippocampus.