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[Meta-analysis of alendronate preventing hip fracture risk of postmenopausal women]
Ting Yuan1, Xiao-lin Li, Chang-qing Zhang
1Orthopedic Department, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China. terrence_yuan@yahoo.com.cn
Objective:
To study the efficacy of alendronate to prevent hip fracture risk of postmenopausal women.
Methods:
Randomized controlled trials in postmenopausal women receiving alendronate or placebo for preventing hip fractures rate were searched from Medline, EMBASE, Cochrane Trial Registry and China Biological Medicine database between January 1980 to December 2007. Key words included hip fractures, alendronate, postmenopausal and placebo-controlled. Language was limited in English and Chinese. The software Revman 4.2 was used to perform meta-analysis.
Results:
Six trials, which included 8610 postmenopausal women, met all our inclusion criteria Meta-analysis showed that alendronate can decrease hip fracture rate (OR = 0.51, 95% CI: 0.34, 0.77).
Conclusion:
Alendronate can reduce significantly hip fracture rate in postmenopausal women.
