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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
Published on: December 24, 2016
[Expressions of Th, DC, NK cells in cervical tissue and the relationship with immune functions]
Cui Ma1, Wei-yuan Zhang, Jian-dong Wang
1Beijing Gynecology and Obstetrics Hospital Affiliated to Capital Medical University, Beijing 100026, China.
Objective:
To investigate the different immune functions in normal cervix, CIN and cervical cancer tissue and the relationship between HPV infection and local cervical immune functions.
Methods:
The morphology, quantity, distribution and optical density of CD4+ Th cells, S-100 dendritic cells and CD57+ NK cells in normal cervical tissue, CIN cervical tissue and cervical cancer tissue were determined by immunohistochemistry and imaging analysis.
Results:
In the precancerous lesions, the numbers of the CD4+ Th cells, S-100+ DC and CD57+ NK cells increased with the disease progression in CIN (P < 0.05). But, after carcinogenesis, the immune cells decreased in local cervix tissue (P < 0.05).
Conclusion:
The local tissue of human cervical precancerous lesions had more heightened immune functions as compared with the cancer tissue.
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