[Role of collagen in intestinal anastomosis formation after the rectum resection]

Influence of ischemia factors on the mechanisms of regeneration of colon tissue after imposition of colon anastomosis in an experiment were studied. In the group of animals with the model of arterial and venous ischemia of colon anastomosis by the methods of morphocytometry and immunomorphology used is studied change microcirculation in the place of anastomosis and also of fibroblasts morphofunctional activity in submucous layer of bowel and loud speaker of collagen I and the III type forming in different terms after the operation. It is shown that the most substantial factors, influencing on the process of intestinal anastomosis cicatrisation, are the phenomena an arterial ischemia and hypoxia of intestinal wall tissues, most expressed on 5-7 days, that in clinical terms requires application of the proper measures of prophylaxis of failure of intestinal wall sutures.