Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Drug-Receptor Bonds01:25

Drug-Receptor Bonds

Drug-receptor bonds are formed through various chemical forces when drugs interact with target cells. Covalent bonds, strong and irreversible, are exemplified by DNA-alkylating anticancer agents that inhibit cell division. However, such irreversible drug binding lacks selectivity and can modify the DNA of the surrounding healthy cells. Covalent binding often contributes to tissue toxicity, as seen with chloroform and paracetamol metabolites binding to the liver, causing hepatotoxicity.
In...
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxidative Dimerization of Thiophene-Substituted Indenone Derivatives.

Chemistry, an Asian journal·2026
Same author

VA1213, a selective COX-2 inhibitor, exhibits antitumor activity by suppressing EGFR, AKT, and ERK1/2 phosphorylation.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Design, Synthesis, and Biological Characterization of Macromolecular Ester Prodrugs of a Selective Cyclooxygenase-2 Inhibitor.

ChemMedChem·2025
Same author

Synthesis and Reactivity of Oligo(ethylene glycol)-Tethered Morita-Baylis-Hillman Dimers in the Formation of Macrocyclic Structures Showing Remarkable Cytotoxicity.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Photophysical and Photochemical Features of Lysine Derivatives Bearing Two Triphenylaminocinnamic-Based Fluorophores.

The journal of physical chemistry. B·2025
Same author

Morita-Baylis-Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands.

ACS medicinal chemistry letters·2025
Same journal

Ligno-Suberized Fruit Periderm as a Mechanically Reinforced Biomacromolecular Composite.

Biomacromolecules·2026
Same journal

Effect of Hydrophilic Brush Length and Hydrophobic Chain on Biodistribution of Polymethacrylate-Based Statistical Copolymers.

Biomacromolecules·2026
Same journal

Multicomponent Micelles with Boosted Stability of Iminoboronates.

Biomacromolecules·2026
Same journal

Stiffening and Toughening Protein Hydrogels by Tuning Electrostatic Interactions.

Biomacromolecules·2026
Same journal

<i>In Situ</i> Bulk and Interfacial Interlocking-Induced Highly Dynamically Entangled Hydrogel of Myocardium-Matching Mechanics, Electrophysiological Functions, and Robust Tissue Adhesion for Cardiac Repair.

Biomacromolecules·2026
Same journal

Eutectogel Electrodes with Self-powered Capability for Flexible Electrophysiological Sensor.

Biomacromolecules·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Multivalent supramolecular dendrimer-based drugs.

Simone Galeazzi1, Thomas M Hermans, Marco Paolino

  • 1Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universitàà di Siena, Via A. Moro, 53100 Siena, Italy.

Biomacromolecules
|December 5, 2009
PubMed
Summary
This summary is machine-generated.

Researchers created novel supramolecular complexes using a hydrophobic dendrimer host and bioactive guest molecules. These assemblies demonstrate binding to both natural serotonin receptors and the synthetic dendrimer receptor in aqueous solution.

More Related Videos

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
16:19

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors

Published on: September 10, 2013

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Related Experiment Videos

Last Updated: Jun 18, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
16:19

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors

Published on: September 10, 2013

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Dendrimers are highly branched macromolecules with unique properties.
  • Supramolecular chemistry focuses on noncovalent interactions to create complex assemblies.
  • Bioactive molecules often require specific environments for optimal function.

Purpose of the Study:

  • To synthesize and characterize supramolecular complexes using a hydrophobic dendrimer host and bioactive guest molecules.
  • To investigate the self-assembly and stability of these complexes in aqueous solutions.
  • To evaluate the binding capabilities of the guest molecules to both natural and synthetic receptors.

Main Methods:

  • Noncovalent synthesis of guest-host supramolecular complexes.
  • Preassembly in chloroform followed by transfer to aqueous solution.
  • Characterization of binding affinity to serotonin 5-HT(3) receptors and the dendrimer host.

Main Results:

  • Successful synthesis of supramolecular complexes with a hydrophobic dendrimer host and bioactive guests.
  • Demonstrated ability to transfer the preassembled complexes from organic to aqueous media.
  • Bioactive guests exhibited nanomolar affinity for the natural serotonin 5-HT(3) receptor and the synthetic dendrimer receptor.

Conclusions:

  • The developed supramolecular construct is a dynamic and multivalent system.
  • The system shows potential for adapting to multimeric receptor motifs.
  • This approach offers a novel method for delivering bioactive molecules and creating synthetic receptor mimics.