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Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

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A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
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A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

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Autoimmune pancreatitis.

Sönke Detlefsen1, Asbjørn M Drewes

  • 1Department of Pathology, Odense University Hospital, Odense, Denmark. S.Detlefsen@gmx.net

Scandinavian Journal of Gastroenterology
|December 5, 2009
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis (AIP) is a pancreatic disease causing swelling and fibrosis. Diagnosis involves imaging, serology, and sometimes biopsy or steroid trials to distinguish it from pancreatic cancer.

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Related Experiment Videos

Last Updated: Jun 18, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Autoimmune pancreatitis (AIP) is a distinct form of pancreatitis characterized by pancreatic swelling due to lymphoplasmacytic infiltration and fibrosis.
  • It is increasingly recognized as a manifestation of IgG4-related systemic sclerosing disease.

Purpose of the Study:

  • To review the pathological, radiological, and laboratory findings of AIP.
  • To discuss the treatment and pathogenesis of AIP.

Main Methods:

  • A comprehensive literature search was conducted using PubMed with the keyword "autoimmune pancreatitis".
  • Bibliographies were cross-referenced, and related articles were searched to identify relevant studies.

Main Results:

  • Pathological findings include pancreatic and bile duct narrowing, obstructive jaundice, and parenchymal fibrosis.
  • Histologically, two subtypes exist: one with IgG4-positive plasma cells, the other with granulocytic epithelial lesions (GELs).
  • Diagnosis can be aided by imaging, IgG4 serology, and evaluation of other organ involvement; biopsy and steroid trials are useful for differentiation from pancreatic cancer.

Conclusions:

  • AIP presents with characteristic pathological and clinical features, often linked to IgG4-related disease.
  • Accurate diagnosis requires a combination of imaging, serological tests, and potentially invasive procedures.
  • Treatment response to steroids can be a key diagnostic indicator, differentiating AIP from pancreatic cancer.