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Updated: Jun 18, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Drug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy
Navin Pinto1, Susan M Ludeman, M Eileen Dolan
1University of Chicago, 900 East 57th Street, Room 7100, Chicago, IL 60637, USA.
Abstract:
Cyclophosphamide is a cornerstone in the treatment of many pediatric and adult malignancies, as well as in the treatment of refractory autoimmune conditions. Genetic factors are thought to play a role in the interindividual variation in both response and toxicities associated with cyclophosphamide-based therapies. This drug focus reviews the most compelling studies conducted on the pharmacogenetics of cyclophosphamide-based therapies. Broader pharmacogenomic studies are needed and may reveal additional factors important in susceptibility to toxicity and/or response to therapy.
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