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Cyclosporine a-loaded solid lipid nanoparticles: ocular tolerance and in vivo drug release in rabbit eyes
Evren H Gökçe1, Giuseppina Sandri, Sait Eğrilmez
1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ege, Izmir, Turkey. evren.homan.gokce@ege.edu.tr
Purpose:
To determine the in vivo efficacy of cyclosporine A-loaded solid lipid nanoparticles (SLNs) in rabbit eyes.
Methods:
SLNs were prepared and administered to the cul-de-sac of rabbits, and the drug amount in aqueous humor was detected by high performance liquid chromatography (HPLC). The irritation was evaluated by modified Draize testing.
Results:
The particle size of SLNs was detected as 225.9 +/- 5.5 nm with a negative surface charge. Aqueous humor drug levels reached 50.53 ng/mL, and there was no serious irritation in rabbit eyes.
Conclusions:
Topical ophthalmic efficacy of cyclosporine A was enhanced via administration of SLNs.
