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Updated: Jun 18, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
Tumor regression by means of magnetic drug targeting
M G Krukemeyer1, W Wagner, M Jakobs
1Paracelsus-Klinik Osnabrück, Leiter der Abteilung Strahlenklinik, Abteilung Strahlentherapie, Sedanstr. 109, D-49076 Osnabrück, Germany. dr-krukemeyer@t-online.de
Abstract:
The expression 'magnetic drug targeting' is understood as meaning the targeted administration of a drug, for example, a cytostatic, with the intention of optimizing the local therapeutic effect. A magnetic field strength of 0.6 T is applied externally to the body. Iron oxides are administered intravasally into a vein. Cytostatics are bonded to the iron oxides. This form of administration, also known as sluicing, is particularly suitable for cytostatics, since the intention is to achieve a high concentration of the cytostatic at the target site (site of the tumor), but to minimize the harmful effect in the rest of the tissue. A reduction in tumor volume under the magnetic field and in the liver of 45-90% has been detected by MRI.
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