Related Experiment Video
Updated: Jun 18, 2026
Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
Published on: March 27, 2018
Centers for Disease Control 'high-risk' donors and kidney utilization
K I Duan1, M J Englesbe, M L Volk
1Department of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Insights
Centers for Disease Control high-risk (CDCHR) donor kidneys are less likely to be utilized for transplantation. However, CDCHR status does not negatively impact recipient survival, suggesting potential wastage of viable organs.
Area of Science:
- Nephrology
- Transplantation Medicine
- Public Health
Background:
- Organ donor risk stratification impacts kidney utilization and transplant outcomes.
- Centers for Disease Control high-risk (CDCHR) designation is applied to certain organ donors.
- Understanding the implications of CDCHR status is crucial for optimizing kidney allocation.
Purpose of the Study:
- To evaluate the effect of CDCHR status on kidney utilization rates.
- To determine if CDCHR status influences kidney transplant recipient survival.
- To assess the potential wastage of standard criteria donor (SCD) kidneys due to CDCHR labeling.
Main Methods:
- Analysis of 45,112 SCD deceased donor kidneys from the Scientific Registry of Transplant Recipients (2005-2009).
- Logistic regression used to compare utilization rates between CDCHR and non-CDCHR kidneys.
- Cox regression analyzed posttransplant survival in 25,158 recipients of SCD kidneys (2005-2008).
Main Results:
- CDCHR kidneys were 8.2% less likely to be utilized for transplantation.
- Adjusted analysis showed CDCHR status was associated with a significantly lower odds ratio of utilization (0.67).
- Recipient survival was similar between CDCHR and non-CDCHR kidney recipients after a median 2-year follow-up (HR 1.06).
Conclusions:
- The 'high-risk' designation for organ donors may lead to the underutilization of otherwise viable SCD kidneys.
- CDCHR status does not appear to adversely affect long-term kidney transplant recipient survival.
- Re-evaluation of organ acceptance criteria for CDCHR donors could potentially increase kidney utilization and save lives.
Abstract:
The aims of this study were to determine whether Centers for Disease Control high risk (CDCHR) status of organ donors affects kidney utilization and recipient survival. Data from the Scientific Registry of Transplant Recipients were used to examine utilization rates of 45,112 standard criteria donor (SCD) deceased donor kidneys from January 1, 2005, and February 2, 2009. Utilization rates for transplantation were compared between CDCHR and non-CDCHR kidneys, using logistic regression to control for possible confounders. Cox regression was used to determine whether CDCHR status independently affected posttransplant survival among 25,158 recipients of SCD deceased donor kidneys between January 1, 2005, and February 1, 2008. CDCHR kidneys were 8.2% (95% CI 6.9-9.5) less likely to be used for transplantation than non-CDCHR kidneys; after adjusting for other factors, CDCHR was associated with an odds ratio of utilization of 0.67 (95% CI 0.61-0.74). After a median 2 years follow-up, recipients of CDCHR kidneys had similar posttransplant survival compared to recipients of non-CDCHR kidneys (hazard ratio 1.06, 95% CI 0.89-1.26). These findings suggest that labeling donor organs as 'high risk' may result in wastage of approximately 41 otherwise standard kidneys per year.
Related Concept Videos
01:28Kidney Transplant I: Introduction
01:26Kidney Transplant II: Surgical Procedure
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:16Kidney Transplant III: Nursing Management
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
01:28Chronic Kidney Disease III: Interprofessional Care