Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Genetic Variation

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...

Evolution of Microbial Genome

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...

Genome Copying Errors

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their survival. Therefore, the copying errors are checked and repaired at three levels.

Gene Duplication and Divergence

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sphingosine-1-phosphate receptor 1 signaling stimulates human pluripotent stem cell-derived cardiomyocyte differentiation and maturation.

Experimental & molecular medicine·2026

Same author

Activatable smart contrast agents for photoacoustic imaging.

Smart molecules : open access·2026

Same author

Machine Learning in Nonhuman Primate Models of Infectious Diseases: Current Applications and Future Perspectives.

Journal of the American Association for Laboratory Animal Science : JAALAS·2026

Same author

Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].

Biomedical optics express·2026

Same author

Pulse Repetition Frequency Tuned Low-Intensity Focused Ultrasound Neuromodulation for Tibial Nerve Targeted Bladder Function Modulation.

IEEE transactions on bio-medical engineering·2026

Same author

Lactiplantibacillus plantarum DS1073 protects the gastric mucosa under Helicobacter pylori infection and ethanol stress.

Cell communication and signaling : CCS·2026

Same journal

Model-based quantification of protein-protein interaction aberrations for exploring dysregulated signalling pathways through pathway maps and gene expression levels.

BMC bioinformatics·2026

Same journal

Research on multi-trait genome association study method based on Shannon information entropy.

BMC bioinformatics·2026

Same journal

A multi-view feature fusion framework with interpretable graph convolution for predicting microbe-drug associations.

BMC bioinformatics·2026

Same journal

Covariance decomposition for distance based species tree estimation.

BMC bioinformatics·2026

Same journal

SNPio: a Python interface for population genomic data processing.

BMC bioinformatics·2026

Same journal

SpaHNR: a spatial domain identification method via sparse attention-based hierarchical node representation and multi-view contrastive learning.

BMC bioinformatics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Gevab: a prototype genome variation analysis browsing server.

Woo-Yeon Kim¹, Sang-Yoon Kim, Tae-Hyung Kim

¹Korean BioInformation Center (KOBIC), KRIBB, Daejeon, Korea. kimplove@kribb.re.kr

BMC Bioinformatics

|December 5, 2009

Summary

This summary is machine-generated.

The Korean genome variation analysis and browsing server (Gevab) provides access to Korean personal genome data, including SNPs, indels, and structural variations. This resource facilitates the exploration and download of detailed genomic information for researchers.

More Related Videos

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Related Experiment Videos

Last Updated: Jun 18, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Area of Science:

Genomics
Bioinformatics

Background:

The first Korean individual diploid genome sequence data (KOREF) was released in December 2008.
This established a foundation for Korean genomic research.

Purpose of the Study:

To develop a comprehensive database and web server for Korean personal genomes.
To enable exploration and downloading of Korean genome data.

Main Methods:

Construction of the Korean genome variation analysis and browsing server (Gevab).
Integration of data including SNPs, short indels, and structural variations (SVs).
Comparative analysis against the NCBI human reference genome.

Main Results:

Gevab provides access to assembled consensus sequences and sequenced short reads.
Detailed information on genetic variations and genotype-phenotype relationships is available.
Facilitates comparison between Korean genomes and the human reference.

Conclusions:

The Gevab server is publicly accessible online.
It serves as a valuable resource for researchers studying Korean genomics.