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Matrix metalloproteinase-9 promoter gene polymorphism (-1562C>T) in nasal polyposis
Selim S Erbek1, Erkan Yurtcu, Seyra Erbek
1Department of Otolaryngology, Baskent University, Faculty of Medicine, Ankara, Turkey. selimerbek@gmail.com
Background:
Expression of matrix metalloproteinase (MMP)-9 increases in nasal polyp tissues. However, the impact of MMP-9 genotypes on the development of nasal polyposis (NP) is unknown. The aim of this study was to examine a potential association of MMP-9 promoter gene polymorphism with the development of NP.
Methods:
A prospective and case-control study was performed on 93 patients with NP and 115 controls without sinonasal disease. Genotypes of MMP-9 (-1562C>T) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.
Results:
The frequency of -1562CT genotype of MMP-9 was significantly high in NP patients with aspirin-induced asthma (p = 0.014). Distribution of T allele was significantly high in NP patients with aspirin-induced asthma (p = 0.013). MMP-9 genotypes were not associated with gender or the presence of atopy.
Conclusion:
In this study, MMP-9 -1562CT genotype was associated with susceptibility to NP in aspirin-induced asthmatic patients. Because this report is a population-based study, further research should be performed on larger study subjects to reveal the precise role of MMP-9 promoter gene polymorphism in the development of NP.
Insights
The matrix metalloproteinase (MMP)-9 -1562CT genotype is linked to increased susceptibility to nasal polyposis (NP) in patients with aspirin-induced asthma. Further research is needed to confirm the role of MMP-9 gene polymorphism in NP development.
Area of Science:
- Genetics and Molecular Biology
- Otorhinolaryngology
- Immunology
Background:
- Matrix metalloproteinase (MMP)-9 expression is elevated in nasal polyp tissues.
- The specific impact of MMP-9 gene variants on nasal polyposis (NP) development remains unclear.
- Investigating MMP-9 promoter gene polymorphism offers insight into NP pathogenesis.
Purpose of the Study:
- To investigate the association between MMP-9 promoter gene polymorphism and the development of nasal polyposis (NP).
- To determine if specific MMP-9 genotypes influence NP susceptibility, particularly in relation to aspirin-induced asthma.
Main Methods:
- A prospective case-control study involving 93 NP patients and 115 controls.
- Polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis was used to identify MMP-9 (-1562C>T) genotypes.
- Genotype data was analyzed for associations with NP, aspirin-induced asthma, gender, and atopy.
Main Results:
- The MMP-9 -1562CT genotype was significantly more frequent in NP patients with aspirin-induced asthma (p = 0.014).
- The T allele of MMP-9 was also significantly more prevalent in NP patients with aspirin-induced asthma (p = 0.013).
- No significant association was found between MMP-9 genotypes and gender or the presence of atopy.
Conclusions:
- The MMP-9 -1562CT genotype is associated with an increased susceptibility to NP in individuals with aspirin-induced asthma.
- This population-based study suggests a potential role for MMP-9 promoter gene polymorphism in NP development.
- Larger-scale studies are recommended to elucidate the precise role of MMP-9 gene polymorphism in the pathogenesis of nasal polyposis.
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