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1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells
A Halhali1, G M Acker, M Garabédian
1CNRS URA 583-Université Paris V, Hôpital des Enfants Malades, Paris, France.
Journal of Reproduction and Fertility
|January 1, 1991
Abstract:
Intraluminal injection of female rats at Day 5 of pseudopregnancy with 10-500 ng 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) significantly increased the uterine weight and induced decidual reaction. This effect was observed as early as the 3rd day after 1,25-(OH)2D3 injection. It was detectable only in the injected left horn and not in the non-injected right horn. A 500 ng dose of 25-(OH)D3 had no such effect. The present in-vivo results suggest that 1,25-(OH)2D3 may play a physiological role in endometrial cell differentiation into decidual cells, a crucial step in the process of blastocyst implantation.