Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canagliflozin Alleviates Experimental Antineutrophil Cytoplasmic Antibody-Associated Vasculitis through Suppression of Pathogenic T-Cell Responses.

Journal of the American Society of Nephrology : JASN·2026
Same author

Real-world safety assessment of avacopan in patients with antineutrophil cytoplasmic antibody-associated vasculitis.

RMD open·2026
Same author

Neutrophil CD11b is a pivotal PANoptosis marker correlated with disease activity in antineutrophil cytoplasmic antibody-associated vasculitis.

Apoptosis : an international journal on programmed cell death·2025
Same author

Efficacy and safety of creatine phosphate sodium in the treatment of viral myocarditis: A systematic review and meta-analysis.

PloS one·2025
Same author

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in China: Epidemiology, Management, Prognosis, and Outlook.

Kidney diseases (Basel, Switzerland)·2024
Same author

Landform and lithospheric development contribute to the assembly of mountain floras in China.

Nature communications·2024

Related Experiment Video

Updated: Jun 18, 2026

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling
06:55

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling

Published on: May 26, 2011

[Progress on the subcellular localization of Daxx].

Su-Fang Chen1, Cui-Ming Zhu, Yan-Ping Wan

  • 1Institute of Pathogenic Biology,University of South China, Hengyang, Hunan, 421001,P. R. China.

AI Zheng = Aizheng = Chinese Journal of Cancer
|December 5, 2009
PubMed
Summary
This summary is machine-generated.

Death domain-associated protein (Daxx) is a crucial nuclear protein involved in gene regulation and cellular responses. This review examines how Daxx

More Related Videos

Visualizing Subcellular Localization of a Protein in the Heart Using Quantum Dots-Mediated Immuno-Labeling Followed by Transmission Electron Microscopy
08:13

Visualizing Subcellular Localization of a Protein in the Heart Using Quantum Dots-Mediated Immuno-Labeling Followed by Transmission Electron Microscopy

Published on: September 16, 2022

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans
09:36

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans

Published on: July 30, 2018

Related Experiment Videos

Last Updated: Jun 18, 2026

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling
06:55

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling

Published on: May 26, 2011

Visualizing Subcellular Localization of a Protein in the Heart Using Quantum Dots-Mediated Immuno-Labeling Followed by Transmission Electron Microscopy
08:13

Visualizing Subcellular Localization of a Protein in the Heart Using Quantum Dots-Mediated Immuno-Labeling Followed by Transmission Electron Microscopy

Published on: September 16, 2022

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans
09:36

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans

Published on: July 30, 2018

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Death domain-associated protein (Daxx) is a highly conserved nuclear protein.
  • Daxx participates in critical cellular processes including transcriptional control, carcinogenesis, and antiviral defense.
  • Its known localizations include the nucleoplasm, nucleolus, cytoplasm, heterochromatin, and PML oncogenic domains.

Purpose of the Study:

  • To review the subcellular localization of Daxx under various cellular conditions.
  • To discuss the dynamic translocation of Daxx between different cellular compartments.
  • To explore how Daxx's localization is influenced by post-translational modifications and protein interactions.

Main Methods:

  • Literature review of studies investigating Daxx localization.
  • Analysis of experimental data on Daxx translocation mechanisms.
  • Synthesis of findings on Daxx's interactions and modifications affecting its cellular distribution.

Main Results:

  • Daxx exhibits dynamic subcellular localization.
  • Localization is modulated by cellular stress, protein interactions, and post-translational modifications.
  • These changes impact downstream signaling pathways.

Conclusions:

  • Daxx's subcellular localization is a key regulatory mechanism.
  • Understanding Daxx translocation is vital for comprehending its diverse cellular functions.
  • Further research into Daxx dynamics can offer insights into disease mechanisms and therapeutic strategies.