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Related Experiment Video

Updated: Jun 18, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Idiopathic chilblains.

Shraddha Prakash1, Michael H Weisman

  • 1Cedars-Sinai Medical Center, Los Angeles, Calif., USA.

The American Journal of Medicine
|December 5, 2009
PubMed
Summary
This summary is machine-generated.

Chilblains presents as painful, red-to-purple lesions on extremities. Early recognition of its distinct features, like female sex and low BMI risk factors, aids management and avoids unnecessary tests.

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Last Updated: Jun 18, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Rheumatology
  • Dermatology

Background:

  • Chilblains is a benign condition often misdiagnosed.
  • Mimics vasculitis and peripheral thromboemboli, leading to extensive work-ups.

Observation:

  • Reviewed 3 cases from Rheumatology and 113 documented cases.
  • Chilblains are painful red-to-purple papular lesions on fingers or toes.

Findings:

  • Resolves with symptomatic treatment.
  • Female sex and low body mass index are identified risk factors.

Implications:

  • Distinct clinical features aid early recognition and management.
  • Prevents unnecessary diagnostic testing and delays in patient care.