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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Updated: Jun 18, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Published on: October 14, 2016

Sarcomas across the age spectrum.

Suzanne L Wolden1, Kaled M Alektiar

  • 1Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. woldens@mskcc.org

Seminars in Radiation Oncology
|December 5, 2009
PubMed
Summary

Sarcoma treatment in children and adults shares similarities, with pediatric advances informing adult care and vice versa. Understanding specific sarcoma types across age groups enhances overall knowledge and treatment strategies.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Surgical Oncology

Background:

  • Age significantly impacts cancer treatment, but sarcomas often receive similar approaches in children and adults.
  • Distinct sarcoma subtypes predominantly affect specific age groups, creating unique research and treatment challenges.
  • Cross-generational insights into sarcoma biology and treatment have led to significant therapeutic advancements.

Purpose of the Study:

  • To explore the age spectrum of sarcoma, highlighting similarities and differences in pediatric and adult populations.
  • To illustrate how understanding specific sarcoma types in one age group can inform research and treatment in another.
  • To discuss four distinct sarcoma types: Ewing sarcoma, rhabdomyosarcoma, synovial sarcoma, and liposarcoma, across different age demographics.

Main Methods:

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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  • Comparative analysis of sarcoma treatment approaches across pediatric and adult populations.
  • Review of molecular and clinical advancements in specific sarcoma subtypes.
  • Discussion of therapeutic strategies, including chemotherapy, limb-sparing surgery, and adjuvant radiation.

Main Results:

  • Molecular discoveries in pediatric Ewing sarcoma aided in identifying translocations in adult sarcomas like synovial sarcoma and myxoid liposarcomas.
  • Chemotherapy success in pediatric sarcomas serves as a benchmark for adult treatment protocols.
  • Limb-sparing surgery and adjuvant radiation for adult extremity sarcomas have informed pediatric treatment strategies.

Conclusions:

  • Understanding sarcoma across the age spectrum is crucial for advancing treatment.
  • Intergenerational knowledge exchange in sarcoma research accelerates therapeutic progress.
  • Specific sarcoma types, such as synovial sarcoma, act as important bridges between pediatric and adult oncology.