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Rhabdomyolysis due to primary hyperaldosteronism
José Joaquín Alfaro Martínez1, Cristina Lamas Oliveira, Amparo Lomas Meneses
1Sección de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Albacete, Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, España. jalfaro@ono.com
Rhabdomyolysis can rarely signal primary hyperaldosteronism, a condition causing high blood pressure and low potassium. Suspect primary hyperaldosteronism in rhabdomyolysis patients with hypokalemia and metabolic alkalosis.
Area of Science:
- Endocrinology
- Nephrology
- Neurology
Background:
- Rhabdomyolysis has diverse causes, including trauma and genetic factors.
- Primary hyperaldosteronism presents with hypertension, hypokalemia, and elevated aldosterone.
- Rhabdomyolysis is an uncommon manifestation of primary hyperaldosteronism.
Observation:
- A 42-year-old woman experienced rhabdomyolysis as the initial symptom of primary hyperaldosteronism.
- A literature review identified 16 cases of rhabdomyolysis preceding primary hyperaldosteronism diagnosis.
Findings:
- Rhabdomyolysis can be the presenting sign of primary hyperaldosteronism.
- The combination of rhabdomyolysis, hypokalemia, and metabolic alkalosis suggests primary hyperaldosteronism.
- Aldosterone-producing adenoma is the likely cause when primary hyperaldosteronism is confirmed.
Implications:
- This association highlights the importance of considering endocrine disorders in unexplained rhabdomyolysis.
- Early diagnosis of primary hyperaldosteronism can prevent complications.
- Investigating hypokalemia and metabolic alkalosis in rhabdomyolysis patients is crucial for identifying primary hyperaldosteronism.
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