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P50 Sensory Gating in Infants

P50 Sensory Gating in Infants

Published on: December 26, 2013

Varenicline and P50 auditory gating in medicated schizophrenic patients: a pilot study

Merilyne C Waldo¹, Laurie Woodward, Lawrence E Adler

¹The Denver VAMC VISN19/MIRECC and UC Denver, School of Medicine, Department of Psychiatry, CO 80220, USA. merilyne.waldo@va.gov

Psychiatry Research

|December 5, 2009

Abstract

None:

Most schizophrenic patients have a deficit in auditory sensory gating that appears to be mediated by the alpha-7 nicotinic receptor. This pilot study examines the effects of varenicline, an alpha-7 agonist, on the P50 auditory evoked potential in six schizophrenic patients. The study was canceled because of concerning side effects consistent with those reported by the FDA. However, in this small group of subjects, varenicline did not consistently enhance P50 auditory gating.

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