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[Update on antimicrobial chemotherapy].

V Cattoir1, C Daurel

  • 1Equipe EA 2128, service de microbiologie, CHU Côte-de-Nacre, Interactions hôtes et microorganismes des épithéliums, faculté de médecine de Caen, université de Caen-Basse-Normandie, avenue Côte-de-Nacre, Caen cedex 9, France. cattoir-v@chu-caen.fr

Medecine Et Maladies Infectieuses
|December 5, 2009
PubMed
Summary
This summary is machine-generated.

The development of new antibacterial agents is crucial due to rising bacterial resistance. This review covers recently marketed and investigational antibiotics, highlighting a scarcity of options for multidrug-resistant Gram-negative bacteria.

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Area of Science:

  • Microbiology
  • Pharmacology
  • Clinical Medicine

Background:

  • Antibiotic resistance necessitates continuous development of new antibacterial agents.
  • Innovation in antibacterial drug discovery has slowed, particularly for Gram-negative pathogens.
  • A gap exists between the emergence of resistant bacteria and effective treatment options.

Purpose of the Study:

  • To review systemic antibiotics recently marketed in France.
  • To summarize antibacterial drugs in development and those available internationally.
  • To highlight the properties of new and investigational antibacterial agents.

Main Methods:

  • Literature review of microbiological, pharmacological, and clinical properties.
  • Focus on recently marketed, in-development, and internationally available antibiotics.
  • Analysis of agents targeting multidrug-resistant Gram-positive and Gram-negative bacteria.

Main Results:

  • Several new antibiotics have been marketed for Gram-positive infections.
  • New agents for multidrug-resistant Gram-negative bacteria remain scarce.
  • The review details specific agents like linezolid, daptomycin, tigecycline, ertapenem, doripenem, ceftobiprole, and others.

Conclusions:

  • There is an urgent need for novel antibacterial therapies, especially against multidrug-resistant Gram-negative bacteria.
  • The reviewed agents represent important advancements but gaps in treatment remain.
  • Continued research and development are essential to combat evolving bacterial resistance.