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Updated: Jun 18, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Exercise-induced functional mitral regurgitation in heart failure and preserved ejection fraction: a new entity
Sylvestre Maréchaux1, Julia Terrade, Frédéric Biausque
1Centre Hospitalier Régional et Universitaire de Lille, Service d'explorations fonctionnelles cardiovasculaires, Lille, France.
Abstract:
We report here the worsening of functional mitral regurgitation (MR) during dynamic exercise Doppler echocardiography in four female patients with heart failure and preserved ejection fraction. MR worsened concomitantly to an increase in systolic mitral tenting area and in E/E(a) ratio, whereas local left ventricular (LV) remodelling was not substantially aggravated by exercise. We accordingly suggest that exercise-induced increase in LV filling or left atrial pressure that in turn leads to increase in mitral tenting area worsens functional MR during exercise.
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