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In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
Published on: October 6, 2023
Thyroidal radioactive iodide uptake in the lactating rhesus monkey.
Aysel Ozpinar1, Michael Bruss, David Shelton
1Department of Biochemistry, University of Acibadem, Istanbul, Turkey. aozpinar@acibadem.edu.tr
Laboratory Animals
|December 5, 2009
Summary
Radioactive iodide uptake (RAIU) testing was validated in lactating rhesus monkeys. This study establishes RAIU as a reliable method for assessing thyroid function in this animal model.
Area of Science:
- Endocrinology
- Nuclear Medicine
- Primate Research
Background:
- Radioactive iodide uptake (RAIU) is crucial for diagnosing human thyrotoxicosis.
- Limited data exist on RAIU during pregnancy and lactation in humans and animals.
- Validating RAIU in a primate model is essential for thyroid disease research.
Purpose of the Study:
- To validate the radioactive iodide uptake (RAIU) test in lactating rhesus monkeys.
- To establish RAIU as a reliable method for thyroid function assessment in this animal model.
- To support future human thyroid disease studies using rhesus monkeys.
Main Methods:
- RAIU was performed on four lactating rhesus monkeys using 100 microCi of (123)I orally.
- Measurements were taken at 6 and 24 hours post-administration.
- Thyroid and thigh counts were analyzed using a scintillation probe and multichannel analyzer.
Main Results:
- Thyroidal RAIU showed significant variation among individual monkeys.
- The mean 6-hour uptake was 6.71 +/- 2.40%.
- The mean 24-hour uptake was 15.44 +/- 7.71%.
Conclusions:
- The RAIU test is a viable method for thyroid function assessment in lactating rhesus monkeys.
- These findings support the use of rhesus monkeys as a model for human thyroid studies.
- Further research is needed to assess RAIU in rhesus monkeys across different ages, genders, and clinical conditions.
