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Aortic augmentation index: reference values in a large unselected population by means of the SphygmoCor device

Julie H Janner1, Nina S Godtfredsen, Steen Ladelund

  • 1Department of Cardiology and Respiratory Medicine, Hvidovre University Hospital, Hvidovre, Denmark. julie.janner@hvh.regionh.dk

American Journal of Hypertension
|December 5, 2009
PubMed

Insights

Reference values for central augmentation index (AIx), a measure of pulse wave reflection, were established using a large population study. This provides crucial data for understanding cardiovascular disease risk.

Area of Science:

  • Cardiology
  • Vascular Physiology
  • Epidemiology

Background:

  • Arterial stiffness and pulse wave reflection are linked to cardiovascular disease (CVD).
  • Pulse wave analysis (PWA) estimates central augmentation index (AIx), reflecting pulse wave reflection.
  • Establishing reference values for AIx is essential for assessing its predictive role in CVD.

Purpose of the Study:

  • To calculate and validate reference values for central augmentation index (AIx).
  • To develop gender-specific equations for AIx estimation.
  • To investigate the relationship between AIx and cardiovascular risk factors.

Main Methods:

  • Utilized data from 4,561 participants in The Copenhagen City Heart Study.
  • Calculated internally validated AIx reference values using the SphygmoCor device.
  • Employed gender-specific multiple regression analyses, adjusting for age, heart rate, and height in a low-risk cohort.

Main Results:

  • AIx was significantly higher in women (30%) than in men (22%), with a curvilinear increase with age.
  • Reported validated reference equations for AIx based on gender, age, heart rate, and height.
  • Observed an increase in AIx with rising cardiovascular disease risk.

Conclusions:

  • A novel, internally validated, gender-specific equation for calculating AIx reference values was developed.
  • The equation incorporates age, heart rate, and height.
  • These reference values aid in assessing cardiovascular disease risk.
Abstract

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