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Updated: Jun 18, 2026

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
Published on: October 17, 2018
Acute subdural hemorrhage associated with rifampicin-induced thrombocytopenia
Sa-Yoon Kang1, Jay Chol Choi, Ji-Hoon Kang
1Department of Neurology, College of Medicine, Cheju National University, Jeju, South Korea. neurokang@cheju.ac.kr
Abstract:
Thrombocytopenia is a major adverse effect of several drug treatments. Rifampicin has been recognized as a cause of immune thrombocytopenia. A 68-year-old woman diagnosed with pulmonary tuberculosis was taking the standard four-drug antituberculosis regimen for 4 months. She presented with decreased responsiveness and headache. Brain MRI revealed subdural hemorrhage along the falx cerebri and high convexity. The platelet count was 8,000 microL(-1). Intracranial hemorrhage due to rifampicin-induced thrombocytopenia has not, to our knowledge, been previously reported. We report a patient with acute subdural hemorrhage associated with rifampicin-induced thrombocytopenia.
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The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
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