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Related Experiment Video

Updated: Jun 18, 2026

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ
08:44

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ

Published on: June 5, 2018

Image analysis and quantitative morphology.

Carlos Alberto Mandarim-de-Lacerda1, Caroline Fernandes-Santos, Marcia Barbosa Aguila

  • 1Laboratory of Morphometry and Cardiovascular Morphology, Institute of Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Methods in Molecular Biology (Clifton, N.J.)
|December 5, 2009
PubMed
Summary

Quantitative morphometry using stereology enables unbiased analysis of biological structures. This guide explains efficient stereological methods for accurate, low-effort, and cost-effective research in developmental biology, pathology, and neurosciences.

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Area of Science:

  • Quantitative biology
  • Morphometry
  • Neuroscience

Background:

  • Quantitative studies are prevalent in development/evolution, pathology, and neurosciences.
  • Image digitalization converts physical tissue into digital pixels for analysis.
  • Stereology infers 3D structure from 2D slices, requiring unbiased sampling and tools.

Purpose of the Study:

  • To provide a background guide on quantitative morphometry for non-expert morphologists.
  • To explain the principles and efficiency of stereology in biological research.
  • To highlight the importance of unbiased sampling and modern stereological tools.

Main Methods:

  • Image digitalization and analysis for automatic morphometry.
  • Stereological principles for inferring 3D structure from 2D sections.
  • Isotropic and uniform random sampling techniques for unbiased data acquisition.

Main Results:

  • Stereology allows unbiased and reproducible quantification of morphological structures.
  • Efficient stereology minimizes counting, reduces costs, and maintains accuracy.
  • The guide offers a foundational understanding for applying stereology.

Conclusions:

  • Stereology is an efficient method for quantitative morphological studies.
  • Proper application of stereology requires appropriate sampling and tools.
  • This guide facilitates the use of stereology by non-expert morphologists.