Receptor guanylyl cyclase C (GC-C): regulation and signal transduction

Nirmalya Basu1, Najla Arshad, Sandhya S Visweswariah

  • 1Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India.

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...