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Updated: Jun 18, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Zinc triflate: a highly efficient reusable catalyst in the synthesis of functionalized quinolines via Friedlander
Kushal C Lekhok1, Debajyoti Bhuyan, Dipak Prajapati
1Department of Medicinal Chemistry, North East Institute of Science and Technology, Jorhat, Assam, 785 006, India.
Abstract:
An environmentally friendly and highly efficient procedure for the preparation of quinolines and fused polycyclic quinolines has been developed by a simple Friedlander annulation reaction of 2-aminoaryl ketone with carbonyl compounds in presence of zinc triflate under microwave irradiation and solvent-free conditions. The reaction also proceeds effectively when In(OTf)(3) was used in lieu of Zn(OTf)(2) as the catalyst. The catalyst can be recovered after the reaction and reused efficiently in subsequent runs.
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