[Morphometric analysis of regression of breast cancer after radiotherapy and thermoradiotherapy]

A study was made of 50 infiltrating breast carcinomas, stages II-III, treated with a combined method with or without local UHF-hyperthermia. The object of investigation were cytological and histological specimens, histotopographic tumor slices. Methods of mathematical analysis of correlations between tumor tissue regression and parameters of parenchymal differentiation in cytological specimens and an area of tumor nodes were employed. Tumor tissue regression and differentiation of cell elements in cytological specimens showed correlation in the course of combined treatment on the basis of radiotherapy. Insignificant correlation was revealed between a volumetric density of the tumor parenchyma, preserved after combined treatment with UHF-hyperthermia, and parameters of cell differentiation in cytological specimens. Significantly positive correlation was found between an area of tumor nodes and an area of necrotic foci, developing in them after thermoradiotherapy.