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Updated: Jun 18, 2026

Murine Fetal Echocardiography
Published on: February 15, 2013
Who should be offered fetal echocardiography? One center's experience with 3965 cases
Reuven Sharony1, Moshe D Fejgin, Tal Biron-Shental
1Genetic Institute, Meir Hospital-Sapir Medical Center, Kfar Saba, Israel. sharony@clalit.org.il
Insights
Fetal echocardiography (FE) is useful for detecting congenital heart disease (CHD). A suspicious level II ultrasound or polyhydramnios significantly increases the likelihood of detecting significant CHD.
Area of Science:
- Cardiology
- Prenatal Diagnosis
- Medical Imaging
Background:
- Comprehensive fetal heart evaluation often requires fetal echocardiography (FE) by pediatric cardiologists.
- Economic factors necessitate careful patient selection for FE.
- Understanding referral indications is crucial for optimizing FE utility.
Purpose of the Study:
- To assess the diagnostic value of fetal echocardiography (FE) in identifying congenital heart disease (CHD).
- To analyze the effectiveness of FE based on different referral indications.
Main Methods:
- Retrospective analysis of 3965 fetal echocardiography (FE) studies conducted between January 2000 and December 2004.
- Classification of diagnosed cardiac anomalies into significant and non-significant malformations.
- Calculation of relative risk for detecting CHD based on referral indications: abnormal obstetric scans, maternal/family history, medication use, and maternal request.
Main Results:
- Overall, 228 (5.8%) cases of congenital heart disease (CHD) were identified.
- Suspicion of CHD during four-chamber view or level II ultrasound scans was the most frequent referral indication.
- No correlation was observed between maternal age or gestational age and the detection rate of CHD.
Conclusions:
- Suspicious findings on level II ultrasound scans are a key indicator for fetal echocardiography (FE).
- The presence of polyhydramnios is also an important indication for FE in detecting significant congenital heart disease (CHD).
Background:
Although the comprehensive evaluation of the fetal heart includes echocardiography by an experienced pediatric cardiologist, economic constraints sometimes dictate the need to select patients.
Objectives:
To analyze the usefulness of fetal echocardiography in the detection of congenital heart disease according to the referral indication.
Methods:
This retrospective survey relates to all 3965 FE studies performed in our center from January 2000 to December 2004. The diagnosed cardiac anomalies were classified as significant and non-significant malformations. All FE studies were done by a single operator (A.L.) at Meir Medical Center, a referral center for a population of about 400,000. The 3965 FE studies were performed for the following indications: abnormal obstetric ultrasound scans, maternal and family history of cardiac malformations, medication use during the pregnancy, and maternal request. The relative risk of detecting CHD was calculated according to the various referral indications.
Results:
Overall, 228 (5.8%) cases of CHD were found. The most common indication for referral was suspicion of CHD during a four-chamber view scan in a basic system survey or during a level II ultrasound survey. No correlation was found between maternal age and gestational age at the time of scanning and the likelihood of finding CHD.
Conclusions:
Our data suggest that a suspicious level II ultrasound orthe presence of polyhydramnios is an important indication for FE in the detection of significant CHD.
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