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[Study on effects of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose
Hong-Zhou Yang1, Ming-Mei Zhou, Ai-Hua Zhao
1Center for Chinese Medical Therapy and Systems Biology, Shanghai University of TCM, Shanghai 211203, China.
Objective:
To observe the activities of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase (AR) by a screening model of aldose reductase inhibitor (ARI) in vitro.
Methods:
The inhibition of AR by baicalin, berberine and Astragalus polysaccharides and positive drug (Epalrestat) in different concentrations were evaluated, and their combinative effects were studied according to orthogonal t design.
Results:
Baicalin and berberine had remarkable inhibitory effects on AR, the inhibitory rates were (88.4 +/- 7.4)% and (69.0 +/- 9.4)% at the concentration of 300 microg/mL. However, the combinative effect of the inhibition on AR by the two compounds was antagonistic action. Astragalus polysaccharides had no activity of inhibition on AR.
Conclusion:
Baicalin and berberine are the potential AR inhibitors as they can inhibit the activity of AR in vitro.
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