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[Integrative medical research thinking on the Constitution-subhealth-disease relation developing axis]
1Zhongshan Hospital, Wuhan. 2000jhw@163.com
Summary
This study introduces a new research framework, the "Constitution-Subhealth-Disease Relation Developing Axis," to understand disease progression. It identifies key factors and quantitative changes from health to disease, offering insights into illness development.
Area of Science:
- Integrative Medicine
- Systems Biology
- Pathophysiology
Context:
- Understanding disease development requires exploring the transition from health through sub-health to illness.
- Traditional Chinese Medicine (TCM) concepts of body constitution offer a unique perspective on individual health trajectories.
Purpose:
- To introduce a novel research framework, the "Constitution-Subhealth-Disease Relation Developing Axis," for analyzing disease progression.
- To elucidate the objective rules and key factors governing the quantitative and qualitative changes in disease development.
- To integrate TCM body constitution theory with physiological and pathological indices.
Summary:
- The proposed axis uses body constitution as a core, with coordinates representing physiological and pathological indices of accumulated illness in a sub-health state.
- It identifies key factors that promote disease onset and induce qualitative changes.
- Research is oriented both horizontally (across individuals with similar constitutions) and longitudinally (within the same individual over time).
Impact:
- Provides a new paradigm for studying the continuum from health to disease, incorporating individual constitutional differences.
- Facilitates a deeper understanding of the common pathways of disease development across diverse constitutions.
- Offers a framework for identifying early warning signs and personalized interventions for sub-health and disease prevention.
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