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Updated: Jun 18, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Functional and multifunctional nanoparticles for bioimaging and biosensing.

Subramanian Tamil Selvan¹, Timothy Thatt Yang Tan, Dong Kee Yi

¹Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602. subramaniant@imre.a-star.edu.sg

Langmuir : the ACS Journal of Surfaces and Colloids

|December 8, 2009

Summary

This summary is machine-generated.

We synthesized functional nanoparticles (NPs) for bioimaging and biosensing. Silica coating creates water-soluble NPs for applications like live cell imaging and protein detection.

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Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science

Background:

Functional and multifunctional nanoparticles (NPs) are crucial for advanced bioimaging and biosensing.
Developing water-soluble NPs is essential for effective biological applications.

Purpose of the Study:

To describe the synthesis of functional and multifunctional NPs for bioimaging and biosensing.
To review silica coating approaches for creating water-soluble NPs.
To demonstrate the utility of silica-coated NPs in live cell imaging and protein detection.

Main Methods:

Synthesis of functionalized NPs including quantum dots (QDs), magnetic particles (MPs), and noble metal NPs.
Application of diverse silica coating approaches (reverse microemulsion, thin silanization) for water solubility.
Functionalization of silica-coated NPs with antibodies, oligonucleotides, biotin, and dextran.

Main Results:

Successfully synthesized water-soluble functional and multifunctional NPs.
Demonstrated silica-coated bifunctional NPs (MPs and QDs) for live cell imaging of HepG2 and NIH-3T3 cells.
Showcased efficient protein detection using silica-coated NPs functionalized with various biomolecules.

Conclusions:

Silica coating is an effective strategy for producing water-soluble NPs for bioimaging and biosensing.
Functionalized silica-coated NPs offer versatile platforms for cellular imaging and molecular detection.
The developed NPs hold significant potential for advancing diagnostic and research tools in biomedical fields.