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Updated: Jun 18, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Fetal sex, social support, and postpartum depression.

Ri-hua Xie1, Guoping He, Diana Koszycki

  • 1Obstetrics, Maternal, and Neonatal Investigations (OMNI) Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|December 8, 2009
PubMed
Summary

Giving birth to a baby girl increases the risk of postpartum depression (PPD) in Chinese women due to insufficient postnatal social support. This highlights the critical role of support after childbirth for maternal mental health.

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Area of Science:

  • Reproductive Health
  • Maternal Mental Health
  • Sociology of Health

Background:

  • Postpartum depression (PPD) is a significant global health concern.
  • The influence of fetal sex on PPD risk is an area requiring further investigation.
  • Social support is recognized as a crucial factor in maternal well-being.

Purpose of the Study:

  • To investigate the relationship between fetal sex and the risk of postpartum depression (PPD).
  • To determine the mediating role of prenatal and postnatal social support in this association.
  • To examine these factors within a Chinese population context.

Main Methods:

  • Prospective cohort study conducted in Changsha, China (February-September 2007).
  • Comparison of sociodemographic, obstetric, and social support characteristics between mothers of male and female infants.
  • Logistic regression models used to analyze the association between fetal sex and PPD, with adjustments for various factors.

Main Results:

  • Women giving birth to female infants reported significantly lower postnatal social support.
  • Fetal sex was associated with a 3.67-fold increased odds of PPD for female infants.
  • The elevated PPD risk linked to female infants persisted after accounting for sociodemographic, obstetric factors, and prenatal support, but was eliminated by adjusting for postnatal support.

Conclusions:

  • The heightened risk of postpartum depression in Chinese women delivering female infants is attributable to inadequate social support post-childbirth.
  • Postnatal social support is a critical protective factor against PPD in this demographic.
  • Interventions aimed at enhancing postnatal social support may mitigate PPD risk associated with delivering a female infant.