Aleutian mink disease virus and humans

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Jørgen R Jepsen1, Francesco d'Amore, Ulrik Baandrup

  • 1Department of Occupational Medicine, Hospital of South-Western Jutland, Østergade 81-83, DK-6700 Esbjerg, Denmark. joergen.riis.jepsen@svs.regionsyddanmark.dk

Emerging Infectious Diseases
|December 8, 2009
PubMed

Insights

Aleutian mink disease parvovirus (AMDV) may be linked to human vascular disease. Researchers found AMDV antibodies and DNA in two mink farmers, suggesting a potential role in human illness.

Area of Science:

  • Veterinary Virology
  • Human Infectious Diseases
  • Zoonotic Pathogens

Background:

  • Aleutian mink disease parvovirus (AMDV) primarily affects mink.
  • Human infections with AMDV are exceptionally rare.
  • Vascular disease and microangiopathy are observed in AMDV-infected mink.

Purpose of the Study:

  • To investigate a potential link between AMDV and human vascular disease.
  • To explore the possibility of AMDV as a zoonotic pathogen.

Main Methods:

  • Serological testing for AMDV-specific antibodies.
  • Molecular detection of AMDV DNA in human samples.

Main Results:

  • Two mink farmers presented with symptoms similar to Aleutian disease in mink.
  • AMDV-specific antibodies were detected in both farmers.
  • AMDV DNA was identified in both farmers.

Conclusions:

  • AMDV infection is suspected in two human cases with vascular disease.
  • These findings suggest AMDV may play a role in human disease.
  • Further research is warranted to confirm AMDV's zoonotic potential.

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