Related Experiment Video

Updated: Jun 18, 2026

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

[Association between hemoglobin scavenger receptor CD163 expression and coronary atherosclerotic severity in patients

Li-yuan Zou1, Chao-quan Peng, Cui-zhi Li

  • 1Department of Cardiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|December 8, 2009
PubMed

Insights

Hemoglobin scavenger receptor (CD163) expression on monocytes is elevated in coronary heart disease (CHD) patients. Higher CD163 levels correlate with increased coronary atherosclerosis severity and inflammatory markers like CRP and LDL-C.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomarkers

Context:

  • Coronary heart disease (CHD) is a leading cause of mortality worldwide.
  • Atherosclerosis, the underlying pathology of CHD, involves chronic inflammation.
  • Monocytes play a crucial role in the inflammatory processes of atherosclerosis.

Purpose:

  • To investigate the association between CD163 expression on monocytes and coronary atherosclerotic severity in CHD patients.
  • To explore the role of CD163 in inflammation and lipid peroxidation within the context of CHD.

Summary:

  • Monocyte surface CD163 expression levels were significantly higher in CHD patients compared to controls.
  • Expression levels increased progressively from stable angina to unstable angina and acute myocardial infarction groups.
  • CD163 expression positively correlated with coronary artery disease severity (Jenkins score), C-reactive protein (CRP), and low-density lipoprotein cholesterol (LDL-C).

Impact:

  • CD163 may serve as a potential biomarker for assessing coronary atherosclerotic severity.
  • Understanding CD163's role could offer new therapeutic targets for managing CHD.
  • This study highlights the link between monocyte-associated CD163 and key indicators of cardiovascular risk.
Abstract

More Related Videos

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...