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Particle size of inhaled corticosteroids: does it matter?
Chet Leach1, Gene L Colice, Allan Luskin
1Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Abstract:
A question with respect to asthma therapy revolves around the issue of whether better efficacy occurs with an ultrafine-particle inhaled corticosteroid because of better lung deposition into the distal airways. This article reviews particle size and delivery devices of different steroids, clinical outcomes of small- versus large-particle steroids, and the issue of pharmacoeconomics.
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