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Updated: Jun 18, 2026

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

Physiologic compliance in engineered small-diameter arterial constructs based on an elastomeric substrate.

Peter M Crapo¹, Yadong Wang

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. pcrapo@exponent.com

|December 8, 2009

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Engineering compliant arterial grafts using elastomeric scaffolds significantly improves elastin content and mechanical properties. This approach overcomes limitations of rigid materials, paving the way for better small-diameter bypass grafts.

Area of Science:

Biomaterials Engineering
Tissue Engineering
Vascular Biology

Background:

Compliance mismatch in small-diameter bypass grafts leads to intimal hyperplasia and occlusion.
Current engineered grafts lack compliance and sufficient elastin, hindering long-term patency.
Elastomeric scaffolds under dynamic stimulation may yield compliant arterial constructs.

Purpose of the Study:

To compare engineered arterial constructs using rigid poly(lactide-co-glycolide) (PLGA) versus elastomeric poly(glycerol sebacate) (PGS) scaffolds.
To investigate the impact of scaffold material on tissue development, mechanical properties, and extracellular matrix composition.
To determine if elastomeric scaffolds can yield compliant arterial grafts with physiologic elastin content.

Main Methods:

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Elastomeric PGS Scaffolds in Arterial Tissue Engineering

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Tri-layered Electrospinning to Mimic Native Arterial Architecture using Polycaprolactone, Elastin, and Collagen: A Preliminary Study

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Culturing adult baboon arterial smooth muscle cells (SMCs) in tubular, porous PLGA or PGS scaffolds for 10 days.

Assessing scaffold strength, elastic modulus, and deformation characteristics.

Quantifying collagen and insoluble/soluble elastin content in engineered constructs.

Main Results:

PGS constructs exhibited elastic deformation and compliance comparable to native arteries, unlike rigid PLGA constructs.
PGS scaffolds significantly increased insoluble elastin content and decreased collagen content compared to PLGA.
PLGA constructs showed significantly higher elastic modulus and plastic deformation, with minimal elastin incorporation.

Conclusions:

Substrate stiffness critically influences in vitro tissue development and mechanical properties of engineered arteries.
Rigid materials impede elastin deposition into the extracellular matrix, compromising graft function.
Physiologically compliant arterial grafts with substantial elastin can be engineered in vitro using elastomeric scaffolds like PGS.