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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
Is human herpesvirus-8 transmitted by transfusion?
1Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. vamvakase@cshs.org
Abstract:
Studies of human herpesvirus-8 (HHV-8) transmission through transfusion have produced contradictory results. In North America-a region with a low prevalence of HHV-8 infection-3 studies that tested specimens from linked positive-donor/negative-recipient pairs collected before the introduction of white blood cell (WBC) reduction and the extension of red blood cell (RBC) storage found no case of transmission of HHV-8 to 151 transfusion recipients who were HHV-8-seronegative before the transfusion and received components from HHV-8-seropositive donors. In Uganda, a prospective cohort study of pediatric transfusion recipients observed a small (
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