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Updated: Jun 18, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
In vitro antitubercular and antimicrobial activities of 1-substituted quinoxaline-2,3(1H,4H)-diones
P Ramalingam1, S Ganapaty, Ch Babu Rao
1Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh 515 721, India. rammpharm@rediffmail.com
Abstract:
1-((Substituted)methyl)quinoxaline-2,3(1H,4H)-dione (2a-e) and 1-((substituted)acryloyl)quinoxaline-2,3(1H,4H)-dione (4a-c) were synthesized from quinoxaline-2,3(1H,4H)-dione 1 and evaluated for their antimicrobial activities. Results of the antitubercular screening against Mycobacterium tuberculosis H(37)Rv showed that the compounds 2b,3, and 4a were the most effective, with minimum inhibitory concentrations of 8.012, 8.561, and 8.928microg/ml, respectively. All the compounds exhibited significant antibacterial and considerable antifungal activities.
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