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Total-and lipid-associated sialic acid in serum and thrombocytes in patients with chronic heart failure

Canan Topçuoğlu1, Fatma Meriç Yilmaz, Deniz Sahin

  • 1Ankara Training and Research Hospital Department of Clinical Biochemistry, Ankara, Turkey.

Clinical Biochemistry
|December 8, 2009
PubMed

Insights

Total sialic acid (TSA) and lipid-associated sialic acid (LASA) levels are elevated in chronic heart failure (CHF) patients, indicating their potential as biomarkers. Thrombocyte-sialic acid (TrSA) is not a significant marker for CHF.

Area of Science:

  • Biochemistry
  • Cardiology
  • Biomarkers

Background:

  • Chronic heart failure (CHF) is a complex clinical syndrome with significant morbidity and mortality.
  • Sialic acids (SA) are carbohydrate molecules involved in various biological processes, including inflammation and cell adhesion.
  • Understanding the role of different sialic acid fractions in CHF is crucial for identifying novel diagnostic and prognostic markers.

Purpose of the Study:

  • To investigate and compare serum total sialic acid (TSA), lipid-associated sialic acid (LASA), and thrombocyte-sialic acid (TrSA) levels in patients with chronic heart failure (CHF) compared to healthy controls.
  • To explore the relationship between sialic acid levels and established inflammation and prognostic markers in CHF.
  • To determine the potential of TSA, LASA, and TrSA as diagnostic or prognostic indicators in CHF.

Main Methods:

  • A cohort study involving 31 patients with chronic heart failure (CHF) and 38 healthy controls.
  • Serum samples were analyzed for total sialic acid (TSA), lipid-associated sialic acid (LASA), and thrombocyte-sialic acid (TrSA).
  • Traditional inflammation markers (e.g., hs-CRP, ESR) and prognostic markers (e.g., BNP, homocysteine) were also measured.

Main Results:

  • Serum TSA levels were significantly higher in the CHF group (3.08 ± 0.33 mmol/L) compared to the control group (2.60 ± 0.17 mmol/L).
  • Patients with CHF exhibited significantly elevated levels of serum LASA, homocysteine, high-sensitivity C-reactive protein (hs-CRP), brain natriuretic peptide (BNP), and erythrocyte sedimentation rate (ESR).
  • No significant difference in thrombocyte-sialic acid (TrSA) levels was observed between the CHF and control groups.

Conclusions:

  • Elevated serum TSA and LASA levels are associated with chronic heart failure (CHF), independent of coronary artery disease.
  • Thrombocyte-sialic acid (TrSA) does not appear to be a valuable prognostic marker for CHF patients.
  • The observed increase in sialic acid in CHF is likely attributed to the acute phase response and the lipid-associated components.
Abstract

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