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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes
Milena De Riz1, Daniela Galimberti, Chiara Fenoglio
1Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122 Milan, Italy.
Neuroscience Letters
|December 8, 2009
Summary
Progranulin levels in cerebrospinal fluid do not differ in multiple sclerosis (MS) patients compared to controls. These findings suggest progranulin does not play a significant role in MS pathogenesis.
Area of Science:
- Neuroscience
- Immunology
Background:
- Progranulin (PGRN) is implicated in frontotemporal lobar degeneration and inflammatory processes.
- GRN gene mutations are linked to neurodegenerative diseases.
Purpose of the Study:
- To investigate the role of progranulin in multiple sclerosis (MS) pathogenesis.
- To evaluate progranulin cerebrospinal fluid (CSF) levels in MS patients.
Main Methods:
- CSF progranulin levels were measured in 55 MS patients, 35 non-inflammatory neurological disease (NIND) subjects, 7 other inflammatory neurological disease (OIND) subjects, and 8 controls (CON).
- Statistical analyses were performed, stratifying by disease subtype and gender.
Main Results:
- No significant differences in CSF progranulin levels were found between MS patients and NIND, OIND, or CON groups.
- A positive correlation was observed between CSF progranulin levels and age in MS patients (rho=0.29, P=0.03).
Conclusions:
- Progranulin does not appear to be a major factor in the pathogenesis of multiple sclerosis.
- CSF progranulin levels may correlate with age in MS patients.
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